Research Journal of Pharmaceutical Dosage Form and Technology

Shaktikumar C. Shivhare ¹, U. D. Shivhare ², Preeti Srivastav ³, K. G. Malviya ³

Affiliations
1 Sadar Bazar B/H Ram Mandir At Post Paratwada, Dist- Amravati (M.S) Pin code- 444805, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN

Abstract

Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent tinidazole. The second objective was to establish a stable tinidazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.

Keywords

Vaginosis, Lactic Acid Bacillus Spores, Tinidazole, Formulation, Viability, Stability Test.

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Shaktikumar C. Shivhare ¹, K. G. Malviya ¹, Preeti Srivastav ¹, U. D. Shivhare ², U. K. Atneriya ³

Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
3 BM College of Pharmaceutical Education and Research, Indore (M.P), IN

Abstract

The present article aimed at focusing the different courses being conducted to prepare the manpower for the pharmacy profession i.e. each and every field which is directly or indirectly related to the production and sell of drugs. The article also highlights the regulatory bodies involved in designing the syllabus also the content of course at every stage of the course, the practical training that a student should undergo at every level. The brief discussion has been made about the functions of the regulatory bodies. A correlation has been made between the theoretical and practical content of the course with the present professional opportunities and the requirement of the Pharma industries. A little attempt has been made and some views are put through this platform for upgrading the standard of education to bridge the gape between the theoretical approach of the course and present need of the pharmacy profession at the industrial as well as educational level. Pharmacy education in India traditionally has been industry and product oriented. The information presented in this paper may stimulate discussion and critical analysis and planning, and will be of value in further adaptation of the pharmacy education to desired educational outcomes.

Keywords

Pharmacy Education, Regulatory Bodies, PCI, AICTE, India.

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U. D. Shivhare ¹

Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, IN

Abstract

The matrix-type controlled transdermal drug delivery systems were prepared by solvent evaporation method using methanol: dichloromethane (1:1) as solvent for HPMC and ethanol as solvent for Eudragit RL 100 and Eudragit RS 100 (ERL 100 and ERS 100). In the evaluation tests it was found that formulation batch L1 (96.40%) was having more release as compared to formulation L2 (95.52%) but later had much better physicochemical properties and shown cumulative percentage diffusion 96.60% in 24 h. The transdermal patches were evaluated for their In vitro dissolution test and in vitro diffusion test, skin irritation test. Scanning electron microscopy was performed to characterize the transdermal patch.

Keywords

HPMC E15, Atenolol, Solvent Evaporation Method, Transdermal Patch, Dimethyl Sulphoxide.

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